CLEMSON UNIVERSITY
 LARSEN LABORATORY DRUG DELIVERY - BIOMATERIALS - NANOTECHNOLOGY COLLEGE OF ENGINEERING, COMPUTING, AND APPLIED SCIENCE
CHEMICAL AND BIOMOLECULAR ENGINEERING
CONTACT email larsenj at clemson . edu phone 864.656.2621 office 130 Earle Hall
Elizabeth Singleton
NANOMEDICINE TO ENHANCE CT IMAGING IN BRAIN TUMORS funding sources: Creative Inquiry, CU-CIA Collaborators: Angela Alexander-Bryant, Assistant Professor, Department of Bioengineering CT imaging, although a technology that does allow for successful tissue imaging, has been plagued by harmful radiation and contrast agents. The Food and Drug Administration (FDA) lists concerns such as ionizing radiation and reactions in contrast agents or dyes used. Current contrast agents used in CT imaging are iodinated or radioactive. With regards to iodinated contrast agents, patients can present with allergic reactions that can involve skin rashes, bronchospasms, and seizures and can be fatal, as well as vasovagal reactions, neuropathy, nausea and vomiting, and changes in heart rhythm. Novel contrast agents currently being explored to overcome these side effects include gold, bismuth, and iodine nanoparticles. However, these nanoparticles suffer from short circulation times, rapid clearance from tumor microenvironments, and eliciting immunogenic responses. Through encapsulating contrast agents in polymersomes for applications in CT imaging in brain tumors, nanoparticles are able to be targeted to the tumor site, increasing their residence time and distribution in the tumor and decreasing the amount of contrast agent needed for clear visualization.
Jessica Jager
Jordan Drinks
related presentations 1. Beitz, A.; Martin, C.; Scammon, B.; Nguyen, H.; Tatem, L.; Dorsey, R.; Kelly, J. M. “Advancing Computed Tomography Imaging in the Brain through Nanoparticle Contrast Agents.” American Institute of Chemical Engineers Southeastern Regional Conference, Baton Rouge, LA (April 2018). 2. Brown, C.; Singleton, E.; Jager, J.; Marosok, D.; Ramirez, Y.; Hamas, T.; Spitz, J.; Gardener, S.; Garifo, M.; Drinks, J.; Alexander-Bryant, A.; Larsen, J. Polymersomes Facilitate Transport of Gold Nanoparticles into Neuroblastoma Cells, Biomedical Engineering Society Annual Meeting, Pennsylvania Convention Center, Philadelphia, October 19, 2019
Joey LaValla