CLEMSON UNIVERSITY
 LARSEN LABORATORY DRUG DELIVERY - BIOMATERIALS - NANOTECHNOLOGY COLLEGE OF ENGINEERING, COMPUTING, AND APPLIED SCIENCE
CHEMICAL AND BIOMOLECULAR ENGINEERING
CONTACT email larsenj at clemson . edu phone 864.656.2621 office 130 Earle Hall
Mark Pitman
TOWARDS THE DEVELOPMENT OF A SYNTHETIC BLOOD-BORNE PATHOGEN SCAVENGER funding sources: CU-CIA, Creative Inquiry Although self-assembled nanoparticles are extensively used in preclinical testing, the interactions occurring between these amphiphilic polymers and blood is not widely tested. Our group has found that some more hydrophobic block co-polymers has negative effects on blood components, including platelets. We are working to understand why these morphologic changes are occurring and their lasting impact on function and health. Simultaneously, we are interested in the development of a self-assembling blood-borne pathogen scavenger, capable of theranostic applications in HBV. By understanding interactions between whole blood and block co-polymers, we hope to better control therapeutic systems. related presentations 1. Pitman, M.; Maghak, L.; Larsen, J. Self-Assembling Polymer Nanoparticles in Blood Components: Towards In Vivo Virus Capture, 2019 SC EPSCoR State Conference, Greenville SC, April 12, 2019. 2. Pitman, M., Maghak, L., Larsen, J. Polymer Nanoparticle Self-assembly in Whole Blood: Towards In Vivo Virus Capture, 2020 Controlled Release Society Annual Meeting and Exposition, Las Vegas, Nevada, June 2020. 3. Pitman, M., Larsen, J. Polymer Amphiphiles for Directed Self-Assembly Around Hepatitis B Particles, 2020 AIChE Annual Meeting, San Francisco, California. November 2020. related publications 1. Pitman, M. A.; Larsen, J. M. Characterization of Self-Assembling Nanostructures in Whole Blood. Analytical Methods. 3 Apr 2020. doi: https://doi.org/10.1039/D0AY00170H 2. Maghak, L. & Larsen, J. Intact or in Pieces? A Look at How Clinically Approved, Biodegradable Block Co-Polymers Affect Blood Components. ACS Biomater. Sci. Eng. acsbiomaterials.0c00680 (2020). doi:10.1021/acsbiomaterials.0c00680