CLEMSON UNIVERSITY
 LARSEN LABORATORY DRUG DELIVERY - BIOMATERIALS - NANOTECHNOLOGY COLLEGE OF ENGINEERING, COMPUTING, AND APPLIED SCIENCE
CHEMICAL AND BIOMOLECULAR ENGINEERING
MODULATING NANOPARTICLE SHAPE TO ENHANCE BLOOD-BRAIN BARRIER UPTAKE funding sources: Creative Inquiry The physical properties of these nanoparticles have been implicated as important factors in the physical mechanisms of uptake. Properties such as size, shape, charge, and material are all being studied in order to determine how to best assign these nano-vesicles with a desired uptake pathway. Natural uptake targets, such as proteins, are usually not perfectly spherical but rather exhibit a variety of morphologies. Mimicking these morphologies could allow for higher, more specific delivery that imparts less stress upon the body. We aim to extend this application to self-assembled systems, capable of delivering more than one drug simultaneously. Polymersomes have been transformed to achieve a variety of shapes including rods and stomatocytes. We aim to extend this shape change to drug delivery applications, with an increase in the amount of both hydrophobic and hydrophilic compounds retained and an increase in brain targeting through shape alone.
CONTACT email larsenj at clemson . edu phone 864.656.2621 office 130 Earle Hall
Cara Katterman
Christopher Pierce
related presentations 1. L’Amoreaux, N.; Ali, A.; Crum, C.; Suescum, C.; Larsen, J.M. “Modulating polymersome Shape to Enhance Cellular Uptake.” Focus on Creative Inquiry Poster Forum, Clemson, SC (April 3, 2018). 2. Suescum, C.; L’Amoreaux, N. Ali, A.; Crum, C.; Larsen, J.M. “Post-Assembly Manipulation of Polymersome Morphology.” American Institute of Chemical Engineers Southeastern Regional Conference, Baton Rouge, LA (April 2018). 3. L’Amoreaux, N.; Ali, A.; Kelly, J.M. “Development of Persistent Prolate Shaped Polymersomes for Drug Delivery.” International Nanomedicine and Drug Delivery Symposium. Portland, OR. (September 2018) related publications 1. L'Amoreaux, N., Ali, A., Iqbal, S., Larsen, J. (2019). Persistent Prolate Polymersomes for Enhanced Co-Delivery of Hydrophilic and Hydrophobic Drugs. bioRxiv 796201; doi: https://doi.org/10.1101/796201